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Year Number of Results
2007 1
2008 2
2009 1
2010 1
2011 2
2012 6
2013 2
2014 3
2015 2
2016 1
2018 1
2019 1
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2021 4
2024 0

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Page 1
ORMDL3 and allergic asthma: From physiology to pathology.
James B, Milstien S, Spiegel S. James B, et al. J Allergy Clin Immunol. 2019 Sep;144(3):634-640. doi: 10.1016/j.jaci.2019.07.023. Epub 2019 Jul 31. J Allergy Clin Immunol. 2019. PMID: 31376405 Free PMC article. Review.
There is a strong genetic component to asthma, and numerous genome-wide association studies have identified ORM1 (yeast)-like protein 3 (ORMDL3) as a gene associated with asthma susceptibility. However, how ORMDL3 contributes to asthma pathogenesis and its ph …
There is a strong genetic component to asthma, and numerous genome-wide association studies have identified ORM1 (yeast)-like protein …
Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma.
Wu H, Romieu I, Sienra-Monge JJ, Li H, del Rio-Navarro BE, London SJ. Wu H, et al. Allergy. 2009 Apr;64(4):629-35. doi: 10.1111/j.1398-9995.2008.01912.x. Epub 2008 Dec 30. Allergy. 2009. PMID: 19133921 Free PMC article.
BACKGROUND: A genome-wide association study identified ORM1-like 3 (orosomucoid 1-like 3, ORMDL3) as an asthma candidate gene. Single nucleotide polymorphisms (SNPs) in the region including ORMDL3 on chromosome 17q21 were related to childhood asthma risk and …
BACKGROUND: A genome-wide association study identified ORM1-like 3 (orosomucoid 1-like 3, ORMDL3) as an asthma candidate gene. …
ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility.
Pham AK, Miller M, Rosenthal P, Das S, Weng N, Jang S, Kurten RC, Badrani J, Doherty TA, Oliver B, Broide DH. Pham AK, et al. JCI Insight. 2021 Apr 8;6(7):e136911. doi: 10.1172/jci.insight.136911. JCI Insight. 2021. PMID: 33661765 Free PMC article.
ORM1-like 3 (ORMDL3) has strong genetic linkage to childhood onset asthma. To determine whether ORMDL3 selective expression in airway smooth muscle (ASM) influences ASM function, we used Cre-loxP techniques to generate transgenic mice (hORMDL3Myh11eGFP-cre), …
ORM1-like 3 (ORMDL3) has strong genetic linkage to childhood onset asthma. To determine whether ORMDL3 selective expres …
Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways.
Bugajev V, Paulenda T, Utekal P, Mrkacek M, Halova I, Kuchar L, Kuda O, Vavrova P, Schuster B, Fuentes-Liso S, Potuckova L, Smrz D, Cernohouzova S, Draberova L, Bambouskova M, Draber P. Bugajev V, et al. J Lipid Res. 2021;62:100121. doi: 10.1016/j.jlr.2021.100121. Epub 2021 Sep 22. J Lipid Res. 2021. PMID: 34560079 Free PMC article.
Previous studies have shown that endoplasmic reticulum membrane protein ORM1-like protein 3 (ORMDL3) inhibits the activity of SPT and subsequent sphingolipid synthesis. ...The crosstalk between ORMDL3 and 5-LO metabolic pathways was supported by the finding t …
Previous studies have shown that endoplasmic reticulum membrane protein ORM1-like protein 3 (ORMDL3) inhibits the activity of …
The Association of GSDMB and ORMDL3 Gene Polymorphisms With Asthma: A Meta-Analysis.
Zhao CN, Fan Y, Huang JJ, Zhang HX, Gao T, Wang C, Wang T, Hou LF. Zhao CN, et al. Allergy Asthma Immunol Res. 2015 Mar;7(2):175-85. doi: 10.4168/aair.2015.7.2.175. Epub 2014 Dec 18. Allergy Asthma Immunol Res. 2015. PMID: 25729625 Free PMC article.
PURPOSE: ORM1-like 3 (ORMDL3) belongs to a highly conserved protein family which is anchored as transmembrane protein in the endoplasmic reticulum. ...Recent reports suggest that GSDMB and ORMDL3 are associated with asthma in several populations. However, gen …
PURPOSE: ORM1-like 3 (ORMDL3) belongs to a highly conserved protein family which is anchored as transmembrane protein in the e …
A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.
Stein MM, Thompson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Morin A, Washington C 3rd, Nicolae D, Bønnelykke K, Ober C. Stein MM, et al. J Allergy Clin Immunol. 2018 Sep;142(3):749-764.e3. doi: 10.1016/j.jaci.2017.12.974. Epub 2018 Jan 4. J Allergy Clin Immunol. 2018. PMID: 29307657 Free PMC article. Review.
Genotypes in the core region defined by the first genome-wide association study correlate with expression of 2 genes, ORM1-like 3 (ORMDL3) and gasdermin B (GSDMB), making these prime candidate asthma genes, although recent studies have implicated gasdermin A (GSDMA) …
Genotypes in the core region defined by the first genome-wide association study correlate with expression of 2 genes, ORM1-like 3 ( …
Association of ORMDL3, STAT6 and TBXA2R gene polymorphisms with asthma.
Kavalar MS, Balantic M, Silar M, Kosnik M, Korosec P, Rijavec M. Kavalar MS, et al. Int J Immunogenet. 2012 Feb;39(1):20-5. doi: 10.1111/j.1744-313X.2011.01051.x. Epub 2011 Oct 21. Int J Immunogenet. 2012. PMID: 22017802
It is well known that genetic variability contributes to asthma risk. One of the most replicated asthma candidate genes is ORM1-like 3 (Saccharomyces cerevisiae) (ORMDL3), which has been associated with childhood asthma susceptibility. ...Genotyping was performed us …
It is well known that genetic variability contributes to asthma risk. One of the most replicated asthma candidate genes is ORM1-like …
Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma.
Berce V, Kozmus CE, Potočnik U. Berce V, et al. Pharmacogenomics J. 2013 Dec;13(6):523-9. doi: 10.1038/tpj.2012.36. Epub 2012 Sep 18. Pharmacogenomics J. 2013. PMID: 22986918
Recent genome-wide association studies linked childhood asthma with single-nucleotide polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome 17q21. We analyzed the effect of functional SNP rs2872507 in ORMDL3 gene region on the respons …
Recent genome-wide association studies linked childhood asthma with single-nucleotide polymorphisms (SNPs) in ORM1-like protein 3 ( …
ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis.
Siow D, Sunkara M, Dunn TM, Morris AJ, Wattenberg B. Siow D, et al. J Lipid Res. 2015 Apr;56(4):898-908. doi: 10.1194/jlr.M057539. Epub 2015 Feb 17. J Lipid Res. 2015. PMID: 25691431 Free PMC article.
Genome-wide association studies have established a strong correlation between elevated expression of the endoplasmic reticulum protein ORMDL3 and risk for childhood asthma. Here we test the notion that elevated levels of ORMDL3 decrease sphingolipid biosynthesis. .. …
Genome-wide association studies have established a strong correlation between elevated expression of the endoplasmic reticulum protein OR …
Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population.
Yang FF, Huang Y, Li QB, Dai JH, Fu Z. Yang FF, et al. Genet Mol Res. 2012 Dec 19;11(4):4646-53. doi: 10.4238/2012.October.19.1. Genet Mol Res. 2012. PMID: 23096927 Free article.
Single nucleotide polymorphism (SNP)-based genome-wide association studies have revealed that polymorphisms of the ORM1-like 3 (ORMDL3) gene are associated with childhood asthma. We investigated genetic associations of SNPs in and around the ORMDL3 gene with …
Single nucleotide polymorphism (SNP)-based genome-wide association studies have revealed that polymorphisms of the ORM1-like 3 (OR …
22 results